Penile squamous cell carcinoma :a three-year study at BP koirala Memorial Cancer Hospital
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Keywords

Penile
Squamous cell carcinoma
Malignant

Abstract

Background:
Penile cancer is an aggressive and mutilating disease which
deeply affects self-esteem and daily life of the patient. Penile
cancer mostly affects the elderly, seen in people in their sixties
and seventies. Occurrence in younger age is a need of research
of penile neoplasia in young non-circumcised patients.


Materials and Method:

This is a three-year retrospective
study. Data was extracted from the Department of Pathology
and Medical Record section of B.P. Koirala Memorial Cancer
Hospital. All histologically proven cases were included.

The objective of this study was to assess clinical histo-
pathological profile of penile carcinoma.

Results. A total of 114 malignant cases were included out of which most
common age group involved was 50-60 years with mean age
of presentation being 51.6 years. Glans was the commonest
site of involvement in 59 cases (51.7%). Well-differentiated
squamous cell carcinoma was the most common type (71%).
Forty nine patients (43%) presented when the mass size was
4-6 cm and 44 (39%) came with 2-4cm and rest less than 2
cm. Lymphvascular invasion was seen in 15 (13%) out of
114 cases and perineural invasion was seen only in 5 (4.3%)
cases. 20 cases (17.5%) had lymphnodes positive which are
less than 5 lymphnode positive and five (4.3%) had more
than 5 lymphnodes positive.

Conclusion.

Early diagnosis and intervention of the patient ensure high probability of getting
cured because the stage at presentation appears to be the most
vital prognostic indicator for survival.

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References

Phillipo L Chalya, Peter F Rambau, Nestory

Masalu ,Samson Simbila. Ten-year surgical

experiences with penile cancer at a tertiary care

hospital in northwestern Tanzania:a retrospective

study of 236 patients. World Journal of Surgical

Oncology 2015,13:71. DOI 10.1186/s12957-

-0482-0

Silva RS, Silva AC,Nascimento SG,Oliveira CM,

Bonfim CV. Demographic and epidemiological

aspects of mortality from penile cancer. Acta

Paul Enferm. 2014;27:44–7.

Maden C, Sherman KJ, Beckmann AM. History

of circumcisions, medical conditions, sexual

activity and risk of penile cancer. J Nat Cancer

Inst.1993;16:1255–7.

Schoen EJ, Oehrli M, Colby C, Machin

G. The highly protective effect of new born

circumcision against invasive penile cancer.

Pediatrics.2000;105:E36.

Tsen HF, Morgenstern H, Mack T, Peters RK.

Risk factors for penile cancer: results of a

population-based case–control study in Los

Angeles County (United States). Cancer Causes

Control. 2001;12:267–77.

Barnholtz-Sloan JS, Maldonado JL, Pow-sang

J, Giuliano AR. Incidence trends in primary

malignant penile cancer. Urol Oncol. 2007 Sep-

Oct;25(5):361-7.

Pettaway CA, Lance RS, Davis JW. Tumors of

the Penis. In: Kavoussi LR, Partin AW, Novick

AC, Peters CA, editors. Campbell's Urology. Vol

10 ed. Philadelphia, PA: Saunders Elsevier;

p. 901-33.

Reis AA, Paula LB, Paula AA, Saddi VA, Cruz

AD. Aspectos clinicoepidemiologicos associados

ao cancer de penis. Cienc Saude Coletiva.

;15:1105–11.

Annual Report, BP Koirala Memorial Cancer

Hospital 2016, 2017.

Protzel C, Alcaraz A, Horenblas S, Pizzocaro G.

Lymphadenectomy in the surgical management

of penile cancer. Eur Urol. 2009 May;55(5):1075-

DOI: 10.1016/j.eururo.2009.02.021. Epub

Feb 23

Lont AP, Besnard AP, Gallee MP, van Tinteren

H, Horenblas S. A comparison of physical

examination and imaging in determining the

extent of primary penile carcinoma. BJU Int

; 91:493-5.

Gupta DK, Luitel BR , Chalise PR, Subedi

PP,Chapagain S, Thakur DK,Sharma UK,

Gyawali PR, Shrestha GK. Clinicopathological

pattern of penile cancer in a tertiary care centre

in Nepal. J Nepal Med Assoc 2015;53(199):162-

Lau D W, Ong C H, Lim T P, Teo C .Penile

cancer: a local case series and literature review.

Singapore Med J 2015; 56(11): 637-640 doi:

11622/smedj.2015174

M. Pahwa, M. Girotra, A. Rautela, R. Abrahim.

Penile Cancer In India: A Clinicoepidemiological

Study. The gulf journal of oncology, July 2012;7-9

Koifman L, Vides A J, Koifman N, Carvalho J

P, Ornell A A. International Braz J Urol; Vol. 37

(2): 231-243, March - April, 2011

A.RandoSous,M.P ́erez-UtrillaP ́erez,A.

A g u i l e r a B a z ́ a n , A . Ta b e r n e r o G o m e z ,

J.CisnerosLedo,andJ.DelaPe ̃naBarthel

Advances in Urology Volume 2009, Article ID

, 3 pages doi:10.1155/2009/415062

OY Szeto, HC Cheng, WM Ng, KC Ngan. Hong

Kong J Radiol. 2016;19:111-7 | DOI: 10.12809/

hkjr1615362

Sufrin, G, Huben, R. Benign and malignant

lesions of the penis. In: Adult and Pediatric

Urology, 2nd ed, Gillenwater, JY (Ed), Year

Book Medical Publisher, Chicago 1991.

Solsona E, Algaba F, Horenblas S, Pizzocaro

G, Windahl T; EAU Guidelines on Penile

Cancer: Eur Urol. 2004; 46: 18. doi:10.1016/j.

eururo.2004.03.007

Slaton JW, Morgenstern N, Levy DA, Santos

MW Jr, Tamboli P, Ro JY: Tumor stage, vascular

invasion and the percentage of poorly differentiated

cancer: independent prognosticators for inguinal

lymph node metastasis in penile squamous

cancer. J Urol. 2001; 165: 1138-42.

McDougal WS: Carcinoma of the penis: improved

survival by early regional lymphadenectomy

based on the histological grade and depth of

invasion of the primary lesion. J Urol. 1995

Oct;154(4):1364-6.

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